Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines

Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines

Curcumin, the primary bioactive component isolated from turmeric, has been found to possess a variety of biological functions, including anti-leukemia activity. However, the effect of curcumin in different leukemia cells vary. In this study, we demonstrated that curcumin induced the expression of AI...

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Bibliographic Details
Main Authors: Yuru Zhou, Yunyuan Kong, Mei Jiang, Linju Kuang, Jinhua Wan, Shuyuan Liu, Qian Zhang, Kuai Yu, Na Li, Aiping Le, Zhanglin Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Cancer Biology & Therapy
Subjects:
curcumin
inflammasome
pyroptosis
leukemia
gsdmd
Online Access:http://dx.doi.org/10.1080/15384047.2022.2058862

Internet

http://dx.doi.org/10.1080/15384047.2022.2058862

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