Model of Chronic Thromboembolic Pulmonary Hypertension in Rats Caused by Repeated Intravenous Administration of Partially Biodegradable Sodium Alginate Microspheres

Model of Chronic Thromboembolic Pulmonary Hypertension in Rats Caused by Repeated Intravenous Administration of Partially Biodegradable Sodium Alginate Microspheres

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and life-threatening complication of pulmonary embolism. As existing animal models of CTEPH do not fully recapitulate complex disease pathophysiology, we report a new rat model for CTEPH evoked by repetitive embolization of the distal p...

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Bibliographic Details
Main Authors: Andrei A. Karpov, Nikita A. Anikin, Aleksandra M. Mihailova, Sergey S. Smirnov, Dariya D. Vaulina, Leonid A. Shilenko, Dmitry Yu. Ivkin, Alexei Y. Bagrov, Olga M. Moiseeva, Michael M. Galagudza
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
chronic thromboembolic pulmonary hypertension
experimental model
microspheres
pulmonary embolism
rats
sodium alginate
Online Access:https://www.mdpi.com/1422-0067/22/3/1149

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https://www.mdpi.com/1422-0067/22/3/1149

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