6-Shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells in hypoxic/aglycemic conditions

6-Shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells in hypoxic/aglycemic conditions

Abstract Background The development and growth of colorectal cancer based on constitutive activation of numerous signaling pathways that stimulate proliferation and metastasis. Plant-derived agents excel by targeting multiple aspects of tumor progression. Previous investigations have shown that ging...

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Bibliographic Details
Main Authors: Marta Woźniak, Sebastian Makuch, Kinga Winograd, Jerzy Wiśniewski, Piotr Ziółkowski, Siddarth Agrawal
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Complementary Medicine and Therapies
Subjects:
5-fluorouracil
6-shogaol
Autophagy
Chemosensitivity
Colon cancer
Hypoxia
Online Access:http://link.springer.com/article/10.1186/s12906-020-02913-8

Internet

http://link.springer.com/article/10.1186/s12906-020-02913-8

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