SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma

SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma

Abstract Background Neuroblastoma (NB) is the most common extracranial solid tumor occurring during childhood and high-risk NB patients have a poor prognosis. The amplified MYCN gene serves as an important determinant of a high risk of NB. Methods We performed an integrative screen using public NB t...

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Bibliographic Details
Main Authors: Kezhe Tan, Jialin Mo, Meng Li, Yu Dong, Yujie Han, Xi Sun, Yingxuan Ma, Kai Zhu, Wei Wu, Li Lu, Jiangbin Liu, Kewen Zhao, Lei Zhang, Yujie Tang, Zhibao Lv
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
High-risk neuroblastoma
SMAD9
MYCN
Online Access:https://doi.org/10.1186/s13046-022-02563-3

Internet

https://doi.org/10.1186/s13046-022-02563-3

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