HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis

HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis

Abstract Background Metastasis is the leading cause of cancer-related death in non-small cell lung cancer (NSCLC) patients. We previously showed that low HERC5 expression predicts early tumor dissemination and a dismal prognosis in NSCLC patients. Here, we performed functional studies to unravel the...

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Bibliographic Details
Main Authors: Svenja Schneegans, Jana Löptien, Angelika Mojzisch, Desirée Loreth, Oliver Kretz, Christoph Raschdorf, Annkathrin Hanssen, Antonia Gocke, Bente Siebels, Karthikeyan Gunasekaran, Yi Ding, Leticia Oliveira-Ferrer, Laura Brylka, Thorsten Schinke, Hartmut Schlüter, Ilkka Paatero, Hannah Voß, Stefan Werner, Klaus Pantel, Harriet Wikman
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HERC5
NSCLC
Metastasis
DTC
Cancer metabolism
OXPHOS
Online Access:https://doi.org/10.1186/s13046-024-03020-z

Internet

https://doi.org/10.1186/s13046-024-03020-z

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