mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

<p>Abstract</p> <p>Background</p> <p>The mammalian target of rapamycin (mTOR) signalling pathway has a key role in cellular regulation and several diseases. While it is thought that Rheb GTPase regulates mTOR, acting immediately upstream, while raptor is immediately dow...

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Bibliographic Details
Main Authors: Yadav Rahul B, Burgos Pierre, Parker Anthony W, Iadevaia Valentina, Proud Christopher G, Allen Rodger A, O'Connell James P, Jeshtadi Ananya, Stubbs Christopher D, Botchway Stanley W
Format: Article
Language:English
Published: BMC 2013-01-01
Series:BMC Cell Biology
Subjects:
FLIM
FRET
mTOR
GFP
Raptor
Rheb
Online Access:http://www.biomedcentral.com/1471-2121/14/3

Internet

http://www.biomedcentral.com/1471-2121/14/3

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