High-Level Expression, Purification and Large-Scale Production of l-Methionine γ-Lyase from Idiomarina as a Novel Anti-Leukemic Drug

High-Level Expression, Purification and Large-Scale Production of l-Methionine γ-Lyase from Idiomarina as a Novel Anti-Leukemic Drug

l-Methionine γ-lyase (MGL), a pyridoxal 5′-phosphate-dependent enzyme, possesses anti-tumor activity. However, the low activity of MGL blocks the anti-tumor effect. This study describes an efficient production process for the recombinant MGL (rMGL) from Idiomarina constructed using the overexpressio...

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Bibliographic Details
Main Authors: Kui-Ying Huang, Hai-Yan Hu, Yan-Lai Tang, Feng-Geng Xia, Xue-Qun Luo, Jian-Zhong Liu
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Marine Drugs
Subjects:
l-Methionine γ-lyase
purification
production
enzyme
leukemia
anti-leukemic drug
cell proliferation
apoptosis
Online Access:http://www.mdpi.com/1660-3397/13/8/5492

Internet

http://www.mdpi.com/1660-3397/13/8/5492

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