Aligned electrospun poly(l-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-κB pathways

Aligned electrospun poly(l-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-κB pathways

Abstract Delayed wound healing remains a challenge, and macrophages play an important role in the inflammatory process of wound healing. Morphological changes in macrophages can affect their phenotype, but little is known about the underlying mechanism. Aligned electrospun nanofibers have natural ad...

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Bibliographic Details
Main Authors: Jian Xie, Xiaowei Wu, Shang Zheng, Kaili Lin, Jiansheng Su
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Nanobiotechnology
Subjects:
Aligned nanofibers
Macrophage polarization
Inflammation
Wound healing
JAK-STAT
NF-κB
Online Access:https://doi.org/10.1186/s12951-022-01549-9

Internet

https://doi.org/10.1186/s12951-022-01549-9

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