Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing–Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain

Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing–Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain

Multiple sclerosis (MS) is the chronic inflammatory demyelinating disease of the CNS. Relapsing–remitting MS (RRMS) is the most common type of MS. However, the mechanisms of relapse and remission in MS have not been fully understood. While SJL mice immunized with proteolipid protein (PLP) develop re...

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Bibliographic Details
Main Authors: Chie Takano, Takuma Takano, Makoto Masumura, Ryuichi Nakamura, Shuichi Koda, Hiroki Bochimoto, Shigetaka Yoshida, Yoshio Bando
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
relapsing–remitting EAE
MBP
myelin morphology
relapse
ER stress
Online Access:https://www.mdpi.com/1422-0067/24/9/8160

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https://www.mdpi.com/1422-0067/24/9/8160

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