MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures

MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures

Within mitochondrial substructures, MICU1 is shown to mediate Ca2+ control over spatial membrane potential gradients (SMPGs), with alterations in SMPGs following Ca2+ binding to MICU1 resulting in spatial cristae depolarization.

Bibliographic Details
Main Authors: Benjamin Gottschalk, Zhanat Koshenov, Markus Waldeck-Weiermair, Snježana Radulović, Furkan E. Oflaz, Martin Hirtl, Olaf A. Bachkoenig, Gerd Leitinger, Roland Malli, Wolfgang F. Graier
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03606-3

Internet

https://doi.org/10.1038/s42003-022-03606-3

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