Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells

Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells

Objective: Canonical Wnt/β-catenin signaling is a well-studied endogenous regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and inhibiting adipogenesis. However, emerging genetic evidence in humans links a number of Wnt pathway members to body fat distribution, obesity,...

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Bibliographic Details
Main Authors: Devika P. Bagchi, Akira Nishii, Ziru Li, Jennifer B. DelProposto, Callie A. Corsa, Hiroyuki Mori, Julie Hardij, Brian S. Learman, Carey N. Lumeng, Ormond A. MacDougald
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
β-catenin
Wnt signaling
Adipocyte
Adipose tissue
Metabolism
Lipogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301526

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http://www.sciencedirect.com/science/article/pii/S2212877820301526

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