Doxorubicin Impairs Smooth Muscle Cell Contraction: Novel Insights in Vascular Toxicity

Doxorubicin Impairs Smooth Muscle Cell Contraction: Novel Insights in Vascular Toxicity

Clinical and animal studies have demonstrated that chemotherapeutic doxorubicin (DOX) increases arterial stiffness, a predictor of cardiovascular risk. Despite consensus about DOX-impaired endothelium-dependent vasodilation as a contributing mechanism, some studies have reported conflicting results...

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Bibliographic Details
Main Authors: Matthias Bosman, Dustin N. Krüger, Kasper Favere, Callan D. Wesley, Cédric H. G. Neutel, Birgit Van Asbroeck, Owen R. Diebels, Bart Faes, Timen J. Schenk, Wim Martinet, Guido R. Y. De Meyer, Emeline M. Van Craenenbroeck, Pieter-Jan D. F. Guns
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
doxorubicin
cardio-oncology
arterial stiffness
endothelial dysfunction
vascular smooth muscle cell contraction
non-selective cation channel
Online Access:https://www.mdpi.com/1422-0067/22/23/12812

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https://www.mdpi.com/1422-0067/22/23/12812

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