Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

Neuronal activity increases local cerebral blood flow (CBF) to satisfy metabolic demand, yet the role of astrocytes in this phenomenon is controversial. Here, the authors show that astrocytes amplify CBF only when neuronal activity is sustained.

Bibliographic Details
Main Authors: Adam Institoris, Milène Vandal, Govind Peringod, Christy Catalano, Cam Ha Tran, Xinzhu Yu, Frank Visser, Cheryl Breiteneder, Leonardo Molina, Baljit S. Khakh, Minh Dang Nguyen, Roger J. Thompson, Grant R. Gordon
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35383-2

Internet

https://doi.org/10.1038/s41467-022-35383-2

Similar Items