Heparin-Induced Changes of Vascular Endothelial Growth Factor (VEGF<sub>165</sub>) Structure

Heparin-Induced Changes of Vascular Endothelial Growth Factor (VEGF<sub>165</sub>) Structure

Vascular endothelial growth factor-A (VEGF-A), a secreted homodimeric glycoprotein, is a critical regulator of angiogenesis in normal and pathological states. The binding of heparin (HE) to VEGF<sub>165</sub> (the major form of VEGF-A) modulates the angiogenesis-related cascade, but the...

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Bibliographic Details
Main Authors: Ekaterina L. Nemashkalova, Marina P. Shevelyova, Andrey V. Machulin, Dmitry D. Lykoshin, Roman S. Esipov, Evgenia I. Deryusheva
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biomolecules
Subjects:
vascular endothelial growth factor
heparin
protein aggregation
differential scanning calorimetry
Online Access:https://www.mdpi.com/2218-273X/13/1/98

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https://www.mdpi.com/2218-273X/13/1/98

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