Short‐term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone‐induced polycystic ovary syndrome mice

Short‐term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone‐induced polycystic ovary syndrome mice

Abstract Background Polycystic ovary syndrome (PCOS) is a multifactorial endocrinopathy that affects reproduction and metabolism. Mammalian target of rapamycin (mTOR) has been shown to participate in female reproduction under physiological and pathological conditions. This study aimed to investigate...

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Bibliographic Details
Main Authors: Zaixin Guo, Xiaohan Chen, Penghui Feng, Qi Yu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Ovarian Research
Subjects:
Polycystic ovary syndrome
mTOR
Rapamycin
Steroidogenesis
Hyperandrogenism
Online Access:https://doi.org/10.1186/s13048-021-00813-0

Internet

https://doi.org/10.1186/s13048-021-00813-0

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