Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination

Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination

Mechanical force is critical for the interaction between an αβ T cell receptor (TCR) and a peptide-bound major histocompatibility complex (pMHC) molecule to initiate productive T-cell activation. However, the underlying mechanism remains unclear. We use all-atom molecular dynamics simulations to exa...

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Bibliographic Details
Main Authors: Ana C Chang-Gonzalez, Robert J Mallis, Matthew J Lang, Ellis L Reinherz, Wonmuk Hwang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
T-cell receptor
catch bond
mechanobiology
major histocompatibility complex
molecular dynamics
Online Access:https://elifesciences.org/articles/91881

Internet

https://elifesciences.org/articles/91881

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