Comparison of the relative importance of vascular and plasma drug concentrations to the hypotensive effect of telmisartan in rats

Introduction: To clarify the importance of the vascular concentration of an angiotensin II receptor blocker (ARB) to its hypotensive effect, the relationships between the drug concentrations in plasma and vascular tissues and the hypotensive effect after administration of an ARB were compared. Mater...

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Bibliographic Details
Main Authors: Shinji Takai, Hiroshi Sakonjo, Denan Jin
Format: Article
Language:English
Published: SAGE Publications 2016-02-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320316633895