Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia

Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia

Abstract Background Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases. Several studies in solid tumors identified high expression of WEE1 kinase as a poor prognostic factor and repor...

Full description

Bibliographic Details
Main Authors: Andrea Ghelli Luserna Di Rorà, Neil Beeharry, Enrica Imbrogno, Anna Ferrari, Valentina Robustelli, Simona Righi, Elena Sabattini, Maria Vittoria Verga Falzacappa, Chiara Ronchini, Nicoletta Testoni, Carmen Baldazzi, Cristina Papayannidis, Maria Chiara Abbenante, Giovanni Marconi, Stefania Paolini, Sarah Parisi, Chiara Sartor, Maria Chiara Fontana, Serena De Matteis, Ilaria Iacobucci, Pier Giuseppe Pelicci, Michele Cavo, Timothy J. Yen, Giovanni Martinelli
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Hematology & Oncology
Subjects:
Acute lymphoblastic leukemia
WEE1 inhibitor
Chemo-sensitizer agent
G2/M checkpoint
Online Access:http://link.springer.com/article/10.1186/s13045-018-0641-1

Internet

http://link.springer.com/article/10.1186/s13045-018-0641-1

Similar Items