Long-Term <i>Helicobacter pylori</i> Infection Switches Gastric Epithelium Reprogramming towards Cancer Stem Cell-Related Differentiation Program in <i>Hp</i>-Activated Gastric Fibroblast-TGFβ Dependent Manner

Long-Term <i>Helicobacter pylori</i> Infection Switches Gastric Epithelium Reprogramming towards Cancer Stem Cell-Related Differentiation Program in <i>Hp</i>-Activated Gastric Fibroblast-TGFβ Dependent Manner

<i>Helicobacter pylori</i> (<i>Hp</i>)-induced inflammatory reaction leads to a persistent disturbance of gastric mucosa and chronic gastritis evidenced by deregulation of tissue self-renewal and local fibrosis with the crucial role of epithelial–mesenchymal transition (EMT)...

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Bibliographic Details
Main Authors: Gracjana Krzysiek-Maczka, Aneta Targosz, Urszula Szczyrk, Tomasz Wrobel, Malgorzata Strzalka, Tomasz Brzozowski, Jaroslaw Czyz, Agata Ptak-Belowska
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Microorganisms
Subjects:
<i>Helicobacter pylori</i>
gastric cancer
activated fibroblasts
cancer associated fibroblasts (CAFs)
epithelial–mesenchymal transition (EMT)
TGFβ1
Online Access:https://www.mdpi.com/2076-2607/8/10/1519

Internet

https://www.mdpi.com/2076-2607/8/10/1519

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