The protective effects of a novel AT2 receptor agonist, β-Pro7Ang III in ischemia-reperfusion kidney injury

The protective effects of a novel AT2 receptor agonist, β-Pro7Ang III in ischemia-reperfusion kidney injury

Background and purpose: This study investigated the reno-protective effects of a highly selective AT2R agonist peptide, β-Pro7Ang III in a mouse model of acute kidney injury (AKI). Methods: C57BL/6 J mice underwent either sham surgery or unilateral kidney ischemia-reperfusion injury (IRI) for 40 min...

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Bibliographic Details
Main Authors: Tingfang Zhang, Yifang Li, Andrea F. Wise, Ketav Kulkarni, Marie-Isabel Aguilar, Chrishan S. Samuel, Mark Del Borgo, Robert E. Widdop, Sharon D. Ricardo
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
AT2R agonist
Acute kidney injury
Ischemia-reperfusion injury
Macrophages
Fibrosis
Metalloproteinase
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222300344X

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http://www.sciencedirect.com/science/article/pii/S075333222300344X

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