Durable protective efficiency provide by mRNA vaccines require robust immune memory to antigens and weak immune memory to lipid nanoparticles

Durable protective efficiency provide by mRNA vaccines require robust immune memory to antigens and weak immune memory to lipid nanoparticles

The Pegylated lipids in lipid nanoparticle (LNPs) vaccines have been found to cause acute hypersensitivity reactions in recipients, and generate anti-LNPs immunity after repeated administration, thereby reducing vaccine effectiveness. To overcome these challenges, we developed a new type of LNPs vac...

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Bibliographic Details
Main Authors: Xueying Tang, Jiashuo Zhang, Dezhi Sui, Zihan Xu, Qiongfen Yang, Tianyu Wang, Xiaoya Li, Xinrong Liu, Yihui Deng, Yanzhi Song
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Materials Today Bio
Subjects:
mRNA cancer vaccine
Immune memory
Lipid nanoparticles
Sialic acid
Tumor immune cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424000474

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http://www.sciencedirect.com/science/article/pii/S2590006424000474

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