Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1

Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1

Abstract Background Approximately 15% of primary colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with thousands of small mutations—the microsatellite instability (MSI) phenotype. We investigated molecular heterogeneity and tumor immunogenicity in relation to clinical...

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Bibliographic Details
Main Authors: Anita Sveen, Bjarne Johannessen, Torstein Tengs, Stine A. Danielsen, Ina A. Eilertsen, Guro E. Lind, Kaja C. G. Berg, Edward Leithe, Leonardo A. Meza-Zepeda, Enric Domingo, Ola Myklebost, David Kerr, Ian Tomlinson, Arild Nesbakken, Rolf I. Skotheim, Ragnhild A. Lothe
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Genome Medicine
Subjects:
Colorectal cancer
Consensus molecular subtypes
Immunogenicity
Immunotherapy resistance
JAK1
Microsatellite instability
Online Access:http://link.springer.com/article/10.1186/s13073-017-0434-0

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http://link.springer.com/article/10.1186/s13073-017-0434-0

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