Salvage of the 5-deoxyribose byproduct of radical SAM enzymes

Salvage of the 5-deoxyribose byproduct of radical SAM enzymes

5-Deoxyribose is formed from 5′-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine enzymes. Here, the authors identify and biochemically characterize a bacterial salvage pathway for 5-deoxyribose, consisting of three enzymes, and solve the crystal structure of the key aldolase.

Bibliographic Details
Main Authors: Guillaume A. W. Beaudoin, Qiang Li, Jacob Folz, Oliver Fiehn, Justin L. Goodsell, Alexander Angerhofer, Steven D. Bruner, Andrew D. Hanson
Format: Article
Language:English
Published: Nature Portfolio 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05589-4

Internet

https://doi.org/10.1038/s41467-018-05589-4

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