Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation
Chronic heart failure (HF) is a clinical syndrome characterized by functional impairments of the myocardium. Metabolic and clinical changes develop with disease progression. In an advanced state, left ventricular assist devices (LVADs) are implanted for mechanical unloading. Our study aimed to asses...
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2021-09-01
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| Online Access: | https://www.mdpi.com/2218-1989/11/9/615 |
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| author | Marion S. Hilse Tom Kretzschmar Rudin Pistulli Marcus Franz Tarek Bekfani Daniela Haase Sophie Neugebauer Michael Kiehntopf Jan F. Gummert Hendrik Milting P. Christian Schulze |
| author_facet | Marion S. Hilse Tom Kretzschmar Rudin Pistulli Marcus Franz Tarek Bekfani Daniela Haase Sophie Neugebauer Michael Kiehntopf Jan F. Gummert Hendrik Milting P. Christian Schulze |
| author_sort | Marion S. Hilse |
| collection | DOAJ |
| description | Chronic heart failure (HF) is a clinical syndrome characterized by functional impairments of the myocardium. Metabolic and clinical changes develop with disease progression. In an advanced state, left ventricular assist devices (LVADs) are implanted for mechanical unloading. Our study aimed to assess the effects of LVAD implantation on the metabolic phenotypes and their potential to reverse the latter in patients with advanced HF. Plasma metabolites were analyzed by LC–MS/MS in 20 patients with ischemic cardiomyopathy (ICM), 20 patients with dilative cardiomyopathy (DCM), and 20 healthy controls. Samples were collected in HF patients before, 30 days after, and >100 days after LVAD implantation. Out of 188 measured metabolites, 63 were altered in HF. Only three metabolites returned to pre-LVAD concentrations 100 days after LVAD implantation. Pre-LVAD differences between DCM and ICM were mainly observed for amino acids and biogenic amines. This study shows a reversal of metabolite abnormalities in HF as a result of LVAD implantation. The etiology of the underlying disease plays an essential role in defining which specific metabolic parameter is altered in HF and reversed by LVAD implantation. Our findings provide a detailed insight into the disease pattern of ICM and DCM and the potential for reversibility of metabolic abnormalities in HF. |
| first_indexed | 2024-03-10T07:27:09Z |
| format | Article |
| id | doaj.art-8f152033f49e45c9aed6d1b1602ee657 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T07:27:09Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-8f152033f49e45c9aed6d1b1602ee6572023-11-22T14:11:47ZengMDPI AGMetabolites2218-19892021-09-0111961510.3390/metabo11090615Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD ImplantationMarion S. Hilse0Tom Kretzschmar1Rudin Pistulli2Marcus Franz3Tarek Bekfani4Daniela Haase5Sophie Neugebauer6Michael Kiehntopf7Jan F. Gummert8Hendrik Milting9P. Christian Schulze10Department of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, GermanyDepartment of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, GermanyDepartment of Cardiology I—Coronary and Peripheral Vascular Disease, Heart Failure, Münster University Hospital, 48149 Münster, GermanyDepartment of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, GermanyDepartment of Internal Medicine I, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Magdeburg, 39120 Magdeburg, GermanyDepartment of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, GermanyDepartment of Clinical Chemistry and Laboratory Diagnostics, University Hospital Jena, 07747 Jena, GermanyDepartment of Clinical Chemistry and Laboratory Diagnostics, University Hospital Jena, 07747 Jena, GermanyHeart and Diabetes Center NRW, 32545 Bad Oeynhausen, GermanyHeart and Diabetes Center NRW, 32545 Bad Oeynhausen, GermanyDepartment of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, GermanyChronic heart failure (HF) is a clinical syndrome characterized by functional impairments of the myocardium. Metabolic and clinical changes develop with disease progression. In an advanced state, left ventricular assist devices (LVADs) are implanted for mechanical unloading. Our study aimed to assess the effects of LVAD implantation on the metabolic phenotypes and their potential to reverse the latter in patients with advanced HF. Plasma metabolites were analyzed by LC–MS/MS in 20 patients with ischemic cardiomyopathy (ICM), 20 patients with dilative cardiomyopathy (DCM), and 20 healthy controls. Samples were collected in HF patients before, 30 days after, and >100 days after LVAD implantation. Out of 188 measured metabolites, 63 were altered in HF. Only three metabolites returned to pre-LVAD concentrations 100 days after LVAD implantation. Pre-LVAD differences between DCM and ICM were mainly observed for amino acids and biogenic amines. This study shows a reversal of metabolite abnormalities in HF as a result of LVAD implantation. The etiology of the underlying disease plays an essential role in defining which specific metabolic parameter is altered in HF and reversed by LVAD implantation. Our findings provide a detailed insight into the disease pattern of ICM and DCM and the potential for reversibility of metabolic abnormalities in HF.https://www.mdpi.com/2218-1989/11/9/615DCMICMLVADmass spectrometrymetabolomics |
| spellingShingle | Marion S. Hilse Tom Kretzschmar Rudin Pistulli Marcus Franz Tarek Bekfani Daniela Haase Sophie Neugebauer Michael Kiehntopf Jan F. Gummert Hendrik Milting P. Christian Schulze Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation Metabolites DCM ICM LVAD mass spectrometry metabolomics |
| title | Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation |
| title_full | Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation |
| title_fullStr | Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation |
| title_full_unstemmed | Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation |
| title_short | Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation |
| title_sort | analysis of metabolic markers in patients with chronic heart failure before and after lvad implantation |
| topic | DCM ICM LVAD mass spectrometry metabolomics |
| url | https://www.mdpi.com/2218-1989/11/9/615 |
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