Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish

Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish

Introduction: Efficient induction of the otic placode, the developmental origin of the inner ear from human pluripotent stem cells (hPSCs), provides a robust platform for otic development and sensorineural hearing loss modelling. Nevertheless, there remains a limited capacity of otic lineage specifi...

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Bibliographic Details
Main Authors: Tsubasa Saeki, Sho Yoshimatsu, Mitsuru Ishikawa, Chung-Chau Hon, Ikuko Koya, Shinsuke Shibata, Makoto Hosoya, Chika Saegusa, Kaoru Ogawa, Jay W. Shin, Masato Fujioka, Hideyuki Okano
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Regenerative Therapy
Subjects:
Human pluripotent stem cell
Floating culture
Otic placode
Single cell RNA-seq
Hair cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320422000359

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http://www.sciencedirect.com/science/article/pii/S2352320422000359

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