Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice

Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice

Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many within loci that affect disease risk. Here, we created random g...

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Bibliographic Details
Main Authors: Lucienne Chatenoud, Cindy Marquet, Fabrice Valette, Lindsay Scott, Jiexia Quan, Chun Hui Bu, Sara Hildebrand, Eva Marie Y. Moresco, Jean-François Bach, Bruce Beutler
Format: Article
Language:English
Published: The Company of Biologists 2022-06-01
Series:Disease Models & Mechanisms
Subjects:
non-obese diabetic (nod) mice
autoimmune diabetes
type 1 diabetes
genetics
risk locus
protective locus
automated meiotic mapping
Online Access:http://dmm.biologists.org/content/15/6/dmm049484

Internet

http://dmm.biologists.org/content/15/6/dmm049484

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