Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor

Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor

Bone homeostasis is maintained by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. A dramatic decrease in estrogen levels in postmenopausal women leads to osteoclast overactivation, impaired bone homeostasis, and subsequent bone loss. Changes in the gut microbiome affect b...

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Bibliographic Details
Main Authors: Renpeng Peng, Chao Song, Shuangquan Gou, Haiyang Liu, Honglei Kang, Yimin Dong, Yong Xu, Peixuan Hu, Kaiyong Cai, Qian Feng, Hanfeng Guan, Feng Li
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Pharmacological Research
Subjects:
Gut microbiota
Clostridium sporogenes
Indole propionic acid
Osteoclast
Pregnane X receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824000653

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http://www.sciencedirect.com/science/article/pii/S1043661824000653

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