Long-term QT prolongation in monkeys after doxorubicin administration at doses similar to breast cancer therapy

Long-term QT prolongation in monkeys after doxorubicin administration at doses similar to breast cancer therapy

BackgroundStudies in small animals and human patients have suggested that anthracyclines may prolong cardiac repolarization, or at least inhibit repolarization reserve, predisposing to QT prolongation and dangerous arrhythmias such as Torsades de pointes. This association in humans is difficult to c...

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Bibliographic Details
Main Authors: George M. Bodziock, Giselle C. Meléndez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
antracyclines
QT prolongation
monkeys
repolarization reserve
cardiomyopathy
Torsade de point
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1247273/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1247273/full

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