Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia

Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia

Background Angiotensin II type 1 receptor (AT1R) autoantibody (AT1‐AA) was first identified as a causative factor in preeclampsia. Unlike physiological ligand angiotensin II (Ang II), AT1‐AA can induce vasoconstriction in a sustained manner, causing a series of adverse effects, such as vascular inju...

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Bibliographic Details
Main Authors: Jingwei Bian, Jinghui Lei, Xiaochen Yin, Pengli Wang, Ye Wu, Xiaoli Yang, Li Wang, Suli Zhang, Huirong Liu, Michael L. X. Fu
Format: Article
Language:English
Published: Wiley 2019-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiotensin receptor
autoantibody
internalization
preeclampsia
vasoconstriction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.011179

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.011179

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