Application of Plackett–Burman Design for Spectrochemical Determination of the Last-Resort Antibiotic, Tigecycline, in Pure Form and in Pharmaceuticals: Investigation of Thermodynamics and Kinetics

Application of Plackett–Burman Design for Spectrochemical Determination of the Last-Resort Antibiotic, Tigecycline, in Pure Form and in Pharmaceuticals: Investigation of Thermodynamics and Kinetics

Tigecycline (TIGC) reacts with 7,7,8,8-tetracyanoquinodimethane (TCNQ) to form a bright green charge transfer complex (CTC). The spectrum of the CTC showed multiple charge transfer bands with a major peak at 843 nm. The Plackett–Burman design (PBD) was used to investigate the process variables with...

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Bibliographic Details
Main Authors: Ahmed S. El-Shafie, Aseel Yousef, Marwa El-Azazy
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceuticals
Subjects:
tigecycline
TCNQ
charge transfer reaction
design of experiments (DoE)
Plackett–Burman design
pharmaceutical formulation
Online Access:https://www.mdpi.com/1424-8247/15/7/888

Internet

https://www.mdpi.com/1424-8247/15/7/888

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