Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges

Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges

Proteolysis-targeting chimaeras (PROTACs) have been developed to be an emerging technology for targeted protein degradation and attracted the favour of academic institutions, large pharmaceutical enterprises, and biotechnology companies. The mechanism is based on the inhibition of protein function b...

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Bibliographic Details
Main Authors: Chao Wang, Yujing Zhang, Tingting Zhang, Lingyu Shi, Zhongmin Geng, Dongming Xing
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
PROTACs
targeted protein degradation
in clinical
promising treatment
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2076675

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https://www.tandfonline.com/doi/10.1080/14756366.2022.2076675

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