Structural basis of Janus kinase trans-activation

Structural basis of Janus kinase trans-activation

Summary: Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate receptor intracellular domains (ICDs...

Full description

Bibliographic Details
Main Authors: Nathanael A. Caveney, Robert A. Saxton, Deepa Waghray, Caleb R. Glassman, Naotaka Tsutsumi, Stevan R. Hubbard, K. Christopher Garcia
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
janus kinase
cryo-EM
phosphorylation
cytokine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002127

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723002127

Similar Items