MUC16 impacts tumor proliferation and migration through cytoplasmic translocation of P120-catenin in epithelial ovarian cancer cells: an original research

MUC16 impacts tumor proliferation and migration through cytoplasmic translocation of P120-catenin in epithelial ovarian cancer cells: an original research

Abstract Background Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) to the cytoplasm and consequently activates ras homolog (Rho) GTPases R...

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Bibliographic Details
Main Authors: Xin Chen, Xiaoduan Li, Xinjing Wang, Qinyi Zhu, Xiaoli Wu, Xipeng Wang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Cancer
Subjects:
Epithelial ovarian cancer
MUC16
p120-catenin
Proliferation
Migration
Online Access:http://link.springer.com/article/10.1186/s12885-019-5371-4

Internet

http://link.springer.com/article/10.1186/s12885-019-5371-4

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