Fluorination Effects on NOS Inhibitory Activity of Pyrazoles Related to Curcumin

Fluorination Effects on NOS Inhibitory Activity of Pyrazoles Related to Curcumin

A series of new (E)-3(5)-[β-(aryl)-ethenyl]-5(3)-phenyl-1H-pyrazoles bearing fluorine atoms at different positions of the aryl group have been synthesized starting from the corresponding β-diketones. All compounds have been characterized by elemental analysis, DSC as well as NMR (1H, 13C, 19F and 15...

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Bibliographic Details
Main Authors: Carla I. Nieto, María Pilar Cabildo, María Pilar Cornago, Dionisia Sanz, Rosa M. Claramunt, María Carmen Torralba, María Rosario Torres, José Elguero, José A. García, Ana López, Darío Acuña-Castroviejo
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
NOS inhibitors
pyrazoles
tautomerism
fluorine derivatives
curcumin
crystallography
multinuclear NMR
Online Access:http://www.mdpi.com/1420-3049/20/9/15643

Internet

http://www.mdpi.com/1420-3049/20/9/15643

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