Interplay Between Plasma Membrane Lipid Alteration, Oxidative Stress and Calcium-Based Mechanism for Extracellular Vesicle Biogenesis From Erythrocytes During Blood Storage

Interplay Between Plasma Membrane Lipid Alteration, Oxidative Stress and Calcium-Based Mechanism for Extracellular Vesicle Biogenesis From Erythrocytes During Blood Storage

The shedding of extracellular vesicles (EVs) from the red blood cell (RBC) surface is observed during senescence in vivo and RBC storage in vitro. Two main models for EV shedding, respectively based on calcium rise and oxidative stress, have been proposed in the literature but the role of the plasma...

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Bibliographic Details
Main Authors: Anne-Sophie Cloos, Marine Ghodsi, Amaury Stommen, Juliette Vanderroost, Nicolas Dauguet, Hélène Pollet, Ludovic D’Auria, Eric Mignolet, Yvan Larondelle, Romano Terrasi, Giulio G. Muccioli, Patrick Van Der Smissen, Donatienne Tyteca
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
lipid domains
membrane transversal asymmetry
reactive oxygen species
lipidomics
cell vesiculation
cholesterol
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00712/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00712/full

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