Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

Background Personalized neoantigen vaccine could induce a robust antitumor immune response in multiple cancers, whose efficacy could be further enhanced by combining with programmed cell death 1 blockade (α-PD-1). However, the corresponding immune response and synergistic mechanisms remain largely u...

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Bibliographic Details
Main Authors: Yang Zhou, Zhenli Li, Geng Chen, Liman Qiu, Zhixiong Cai, Xiaolong Liu, Hengkai Chen, Xiuqing Dong, Yingjun Shi, Linsheng Cai, Wenhan Liu, Honghao Ye, Jiahe Ouyang
Format: Article
Language:English
Published: BMJ Publishing Group 2022-09-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/9/e004389.full

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https://jitc.bmj.com/content/10/9/e004389.full

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