Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H<sub>2</sub>O<sub>2</sub>-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45

Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H<sub>2</sub>O<sub>2</sub>-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45

The human gastric carcinoma cell line MKN-45 is a prototype of bona fide tumor cells, as it is protected from the NADPH oxidase-1 (NOX-1)-driven HOCl- and nitric oxide (NO)/peroxynitrite apoptosis-inducing signaling pathways by a membrane-associated catalase. The use of inhibitors/scavengers shows t...

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Bibliographic Details
Main Author: Georg Bauer
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Antioxidants
Subjects:
hydrogen peroxide
aquaporin
catalase
tumor cell
apoptosis-inducing signaling
glutathione
Online Access:https://www.mdpi.com/2076-3921/10/10/1585

Internet

https://www.mdpi.com/2076-3921/10/10/1585

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