Red Blood Cell Metabolism in Pyruvate Kinase Deficient Patients

Red Blood Cell Metabolism in Pyruvate Kinase Deficient Patients

Background: Pyruvate kinase deficiency (PKD) is the most frequent congenital enzymatic defect of glycolysis, and one of the most common causes of hereditary non spherocytic hemolytic anemia. Therapeutic interventions are limited, in part because of the incomplete understanding of the molecular mecha...

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Bibliographic Details
Main Authors: Micaela K. Roy, Francesca Cendali, Gabrielle Ooyama, Fabia Gamboni, Holmes Morton, Angelo D’Alessandro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Physiology
Subjects:
red blood cells (erythrocytes)
pyruvate kinase deficiency
metabolomics
oxidative stress
underrepresented minorities
rural America
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.735543/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.735543/full

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