Human iPSC-derived neural stem cells with ALDH5A1 mutation as a model of succinic semialdehyde dehydrogenase deficiency

Human iPSC-derived neural stem cells with ALDH5A1 mutation as a model of succinic semialdehyde dehydrogenase deficiency

Abstract Background Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is an autosomal recessive gamma-aminobutyric acid (GABA) metabolism disorder that can arise due to ALDH5A1 mutations, resulting in severe, progressive, untreatable neurodegeneration. SSADH-D is primarily studied using simpl...

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Bibliographic Details
Main Authors: Xiaodan Chen, Minzhi Peng, Yanna Cai, Chengcheng Zhou, Li Liu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Neuroscience
Subjects:
SSADH-D
Human induced pluripotent stem cells
CRISPR/Cas9
Neural stem cells
Online Access:https://doi.org/10.1186/s12868-022-00755-3

Internet

https://doi.org/10.1186/s12868-022-00755-3

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