Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice

Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice

Abstract Background Genome-wide association studies (GWAS) have reported single-nucleotide polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome-wide significant associations with major depression, but the regulation effect of the risk SNPs on VRK2 as well as their rol...

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Bibliographic Details
Main Authors: Mei-Yu Yin, Lei Guo, Li-Juan Zhao, Chen Zhang, Wei-Peng Liu, Chu-Yi Zhang, Jin-Hua Huo, Lu Wang, Shi-Wu Li, Chang-Bo Zheng, Xiao Xiao, Ming Li, Chuang Wang, Hong Chang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Medicine
Subjects:
Major depression
VRK2
Lower expression
Behavioral abnormalities
Dendritic spines
Online Access:https://doi.org/10.1186/s12916-023-02945-0

Internet

https://doi.org/10.1186/s12916-023-02945-0

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