Antimicrobial and Adjuvant Potencies of Di-<i>n</i>-alkyl Substituted Diazalariat Ethers

Antimicrobial and Adjuvant Potencies of Di-<i>n</i>-alkyl Substituted Diazalariat Ethers

Lariat ethers are macrocyclic polyethers—crown ethers—to which sidearms are appended. 4,13-Diaza-18-crown-6 having twin alkyl chains at the nitrogens show biological activity. They exhibit antibiotic activity, but when co-administered at with an FDA-approved antibiotic, the latter’s potency is often...

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Bibliographic Details
Main Authors: Mohit B. Patel, Helena Spikes, Robert S. Bailey, Thomas Connell, Hannah Gill, Michael R. Gokel, Rebecca Harris, Joseph W. Meisel, Saeedeh Negin, Shanheng Andrew Yin, George W. Gokel
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antibiotics
Subjects:
adjuvant
antibiotic
antibiotic resistance
bacteria
crown ether
cytotoxicity
Online Access:https://www.mdpi.com/2079-6382/12/10/1513

Internet

https://www.mdpi.com/2079-6382/12/10/1513

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