A kinetic modeling platform for predicting the efficacy of siRNA formulations in vitro and in vivo

Summary: We present a computational modeling protocol that can accurately predict changes in both in vitro and in vivo gene expression levels in response to the application of various siRNA formulations. We describe how to use this Python-based pipeline to obtain crucial information, namely maximum...

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Bibliographic Details
Main Authors: Esther H. Roh, Millicent O. Sullivan, Thomas H. Epps, III
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166722006037