Physiologically based pharmacokinetic modeling of tacrolimus for food–drug and CYP3A drug–drug–gene interaction predictions

Physiologically based pharmacokinetic modeling of tacrolimus for food–drug and CYP3A drug–drug–gene interaction predictions

Abstract The immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter‐ and intra‐individual variability can be observed. Underlying causes include the effect of food intake on tacrolimus a...

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Bibliographic Details
Main Authors: Helena Leonie Hanae Loer, Denise Feick, Simeon Rüdesheim, Dominik Selzer, Matthias Schwab, Donato Teutonico, Sebastian Frechen, Maaike van derLee, Dirk Jan A. R. Moes, Jesse J. Swen, Thorsten Lehr
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12946

Internet

https://doi.org/10.1002/psp4.12946

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