Whole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity

Whole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity

Mutations in the <i>GBA1</i> gene represent the major genetic risk factor for Parkinson’s disease (PD). The lysosomal enzyme beta-glucocerebrosidase (GCase) encoded by the <i>GBA1</i> gene participates in both the endolysosomal pathway and the immune response. Disruption of t...

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Bibliographic Details
Main Authors: Tatiana Usenko, Anastasia Bezrukova, Margarita M. Rudenok, Katerina Basharova, Maria I. Shadrina, Petr A. Slominsky, Ekaterina Zakharova, Sofya Pchelina
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
transcriptome
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
conduritol-β-epoxide (CBE)
substantia nigra (SN)
Online Access:https://www.mdpi.com/1422-0067/24/15/12164

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https://www.mdpi.com/1422-0067/24/15/12164

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