The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms

The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms

Summary: Adhesion G protein-coupled receptors (aGPCRs) are a large GPCR class that direct diverse fundamental biological processes. One prominent mechanism for aGPCR agonism involves autoproteolytic cleavage, which generates an activating, membrane-proximal tethered agonist (TA). How universal this...

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Bibliographic Details
Main Authors: Duy Lan Huong Bui, Andrew Roach, Jingxian Li, Sumit J. Bandekar, Elizabeth Orput, Ritika Raghavan, Demet Araç, Richard C. Sando
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723005636

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http://www.sciencedirect.com/science/article/pii/S2211124723005636

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