High serum levels of the C-propetide of type V collagen (PRO-C5) are prognostic for short overall survival in patients with pancreatic ductal adenocarcinoma

High serum levels of the C-propetide of type V collagen (PRO-C5) are prognostic for short overall survival in patients with pancreatic ductal adenocarcinoma

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a pronounced fibrotic tumor microenvironment, which impairs treatment response. Type I and V collagens are responsible for the densely packed fibrils in the tumor fibrosis environment. While the role of the major type I collag...

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Bibliographic Details
Main Authors: Neel I. Nissen, Astrid Z. Johansen, Inna M. Chen, Christina Jensen, Emilie A. Madsen, Carsten P. Hansen, Jeppe Thorlacius-Ussing, Morten Karsdal, Julia S. Johansen, Hadi M. H. Diab, Lars N. Jørgensen, Nicholas Willumsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
cancer
collagen
PDAC
prediction
prognosis
tumor fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1158058/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1158058/full

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