Investigating the Mechanism of Inhibition of Cyclin-Dependent Kinase 6 Inhibitory Potential by Selonsertib: Newer Insights Into Drug Repurposing

Investigating the Mechanism of Inhibition of Cyclin-Dependent Kinase 6 Inhibitory Potential by Selonsertib: Newer Insights Into Drug Repurposing

Cyclin-dependent kinases (CDKs) play significant roles in numerous physiological, and are considered an attractive drug target for cancer, neurodegenerative, and inflammatory diseases. In the present study, we have aimed to investigate the binding affinity and inhibitory potential of selonsertib tow...

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Bibliographic Details
Main Authors: Mohammad Hassan Baig, Mohd. Yousuf, Mohd. Imran Khan, Imran Khan, Irfan Ahmad, Mohammad Y. Alshahrani, Md. Imtaiyaz Hassan, Jae-June Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
drug repurposing
cyclin-dependent kinases
anticancer therapy
MD simulation
molecular docking
drug design and development
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.865454/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.865454/full

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