Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice

Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice

Withaferin-A (WA) is the principle component of Withania somnifera (Ashwagandha). It has several biological activities including anti-cancer, anti-diabetic, neuroprotective, hepatoprotective and immune-modulatory properties. The acute and sub-acute toxicity of oral WA was investigated in mice. In th...

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Bibliographic Details
Main Authors: Saurabh Kumar Gupta, Shraddha Jadhav, Dievya Gohil, Girish Ch. Panigrahi, Rajiv Kumar Kaushal, Khushboo Gandhi, Anand Patil, Preeti Chavan, Vikram Gota
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Toxicology Reports
Subjects:
Withaferin-A
Acute toxicity
Sub-acute toxicity
Pharmacokinetics
No-Observed Adverse Effect Level (NOAEL)
Withania somnifera
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750022001263

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http://www.sciencedirect.com/science/article/pii/S2214750022001263

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