Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin

Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin

Expression and activity of the AMP-activated protein kinase (AMPK) α1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients. Hence there is considerable interest in uncovering signalling vulnerabilities arising from this oncogenic el...

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Bibliographic Details
Main Authors: Kaitlin R. Morrison, Tingting Wang, Kuan Yoow Chan, Eleanor W. Trotter, Ari Gillespie, Michael Z. Michael, Jonathan S. Oakhill, Iain M. Hagan, Janni Petersen
Format: Article
Language:English
Published: The Royal Society 2023-04-01
Series:Open Biology
Subjects:
metformin
AMPK
PRKAA1
mTORC1
α1.S347A
colorectal cancers‌
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.230021

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.230021

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