Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection

Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection

BackgroundRespiratory viral infections are closely associated with COPD exacerbations, hospitalisations, and significant morbidity and mortality. The consequences of the persisting inflammation and differentiation status in virus associated severe disease is not fully understood. The aim of this stu...

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Bibliographic Details
Main Authors: Hong Guo-Parke, Dermot Linden, Aurelie Mousnier, Ian C. Scott, Helen Killick, Lee A. Borthwick, Andrew J. Fisher, Sinéad Weldon, Clifford C. Taggart, Joseph C. Kidney
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Medicine
Subjects:
COPD
bronchial epithelial cells
ALI culture
human rhinovirus
differentiation
host innate response
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.741989/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.741989/full

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